![]() The focus of genetic research for the next generation of mouse models can be considered at three main levels: the genotype, the phenotype and what we term the envirotype.Īt the genotype level, mutations are required that are more closely related to human mutations and genetic variants.Īt the phenotype level, systematic (each mutant mouse line) and systemic (examining all organ systems) analysis of mutant mouse lines is required. ![]() To maximize the potential of the mouse as a model organism, we now face challenges that go beyond simply establishing a mutant line for every gene. The current mouse mutant resources already contain mutations for essentially all genes and markers, but many of these mutations still need to be established in mouse lines as a free resource for the scientific community. ![]() The mouse is the leading mammalian model organism for basic genetic research and to study human diseases. ![]()
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